Package ‘ nlme ’ September 4 , 2009

Package ‘ bear ’

June 29, 2010 Version 2.5.3 Date 2010-06-25 Title Average bioequivalence and bioavailability data analysis tool Author Hsin-ya Lee, Yung-jin Lee Maintainer Yung-jin Lee Depends R (>= 2.10.0), reshape, nlme, sciplot, plotrix, ICSNP, gdata Description An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental anal...

Non-linear mixed-effects pharmacokinetic/pharmacodynamic modelling in NLME using differential equations

The standard software for non-linear mixed-effect analysis of pharmacokinetic/pharmacodynamic (PK/PD) data is NONMEM while the non-linear mixed-effects package NLME is an alternative as long as the models are fairly simple. We present the nlmeODE package which combines the ordinary differential equation (ODE) solver package odesolve and the non-linear mixed effects package NLME thereby enabling...

Package ‘ nlme ’

Package ‘ nlme ’ October 15 , 2009

October 15, 2009 Version 3.1-96 Date 2009-10-15 Priority recommended Title Linear and Nonlinear Mixed Effects Models Author Jose Pinheiro (S version), Douglas Bates (up to 2007), Saikat DebRoy (up to 2002), Deepayan Sarkar (up to 2005), the R Core team. Maintainer R-core <R-core@R-pr...

Package ‘ bear ’ July 21 , 2009

Title Average bioequivalence and bioavailability data analysis tool Author Hsin-ya Lee , Yung-jin Lee Maintainer Hsin-ya Lee Description An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental analysis (NCA), ANOVA (lm) for a standard RT/TR 2x2x2 crossover design and...